![]() ![]() Awareness of these variables can be valuable in counseling patients regarding prognosis and treatment options. Several clinical, pathologic, and treatment variables can help to predict which patients are most likely to have pCR after nCRT for rectal cancer. Complete response was not associated with an increased risk of major postoperative complications. Factors associated with pCR included lower tumor grade, lower clinical T and N stage, higher radiation dose, and delaying surgery by more than 6–8 weeks after the end of radiation, while lack of health insurance was linked with a lower likelihood of pCR. ![]() ResultsĪ total of 23,747 patients were included in the study. Multivariable analysis of the association between clinicopathologic characteristics and pCR was performed, and propensity-adjusted analysis was used to identify differences in postoperative morbidity between pCR and non-pCR patients. Patients with rectal cancer who received nCRT followed by radical resection were included in this study. MethodsĪ retrospective review was performed of the NCDB from 2006 to 2011. The aim of this study was to identify variables that predict pCR after nCRT for rectal cancer and to examine the impact of pCR on postoperative complications. Selection: When removing a note separation results in two blobs merging, the resulting blob is now also selected in ARA mode.Some patients with rectal cancer who receive neoadjuvant chemoradiotherapy (nCRT) achieve a pathologic complete response (pCR) and may be eligible for less radical surgery or non-operative management.The Note Inspector: When algorithms without sibilant detection are in use, the Sibilant Balance parameter is now grayed out.Melodyne essential: The option “Show Fades” that appeared erroneously in the Options menu has been removed.Stand-alone mode: When the Replace Audio command has been used, local playback now correctly reflects the track selection.Melodyne essential: The option “Highlight Notes During Playback” has been added to the Options > Note Editor submenu.Windows: Melodyne’s file name extension is now correctly assigned.Scale changes: If the “Tuning and Mode” option is active when using “Notes Follow Scale Changes”, notes are now moved correctly.Moving an inserted note separation under certain circumstances generated an error message.Changing the pitch reference at high zoom levels under certain circumstances led to a crash.Accidentally dragging a track to the Project Inspector tab under certain circumstances led to a crash.Editing the tempo assignment under certain circumstances led to a crash.Pitch editing: “Monitor When Editing Blobs” now also functions reliably with the arrow keys when pitch shifting.Cache: The location of Melodyne’s internal cache is now displayed in the Preferences dialog in ARA mode too, and you can alter its size.If you would prefer to assign a different key combination to this shortcut, you can do so from the Shortcuts page of the Preferences dialog. The playback function: In ARA mode and when using the transfer plug-in, you can now trigger playback of the current blob selection using the shortcut Alt+Space.Pitch editing: The scale snap behavior for pitch systems with closely spaced alternate stages has been improved.The Mac version is supplied in Universal Binary format with native code for processors from Intel/AMD and Apple. Compatibility: In version 5.2, Melodyne now runs natively on Macs with Apple Silicon processors.Run the update check from your Melodyne Preferences window, or log into your Celemony account and download the installer from there." The most important changes New features and improvements We therefore recommend the update to all users. The update adds native M1 support and contains numerous enhancements and bug fixes for both Windows and Mac as well as for operation within all DAWs. "We’re pleased to announce that we have just released a new Melodyne version 5.2. Native støtte for Apple Silicon er blant nyhetene.
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